Помимо того, какой объясненный @Sankar, существует известная проблема после обновления относительно SQL Server, работающего на Windows 2008 R2 с сервером, работающим на режиме экономии электроэнергии (который идет по умолчанию) и это влияет на производительность запросов особенно, если Ваши серверы не испытывают огромное давление (ЦП мог бы работать как половина медленного для экономии электроэнергии). это это выезда и это ведут блог для деталей.
The debug output you are using indicates you're using a Debian style configuration system. I'm going to refer to this as exim4 in order to make it clear that there is some extra configuration magic occurring beyond the default exim config that comes in the source. Anybody reading this later needs to clearly understand that some of this suggestion does not apply unless they are running Debian style exim configs.
The difference in your -bt output gives a clue:
root@srv02:~# exim -bt root@localhost
R: system_aliases for root@localhost
R: dnslookup for mypersoaddress@gmail.com
mypersoaddress@gmail.com
root@srv02:~# exim -bt root
R: dnslookup for root@mydomain.com
root@mydomain.com
In the first one, it knew to look in the system_aliases router because "localhost" is configured to be one of the domains that is allowed to look in the aliases file. But in the second one, it skipped over that aliases file because "mydomain.com" is not in that list. In exim4, that list is the MAIN_LOCAL_DOMAINS macro.
By my estimation, one of these things is probably going to solve your problem. Items 2 and beyond are potential adjustments to your exim.conf. Since you run exim.4, you need to be adjusting Debian mail configuration files in /etc/exim/ and then run exim4-conf.conf or something like that to have those changes read in and generate the new configuration file (/var/lib/exim4/config.autogenerated*) that exim4 actually uses.: